Rilmazafone for sale

Curious about what is Rilmazafone Rhythmy 450191 S and why research labs seek it out worldwide. Discover how this benzodiazepine prodrug behaves, its mechanisms, legal grey zones, and how our high purity Rilmazafone at Davechemicals.com supports advanced, non clinical research only. Our Rilmazafone Rhythmy 450191 S is a high purity, research grade benzodiazepine prodrug supplied strictly for laboratory use, not for human or veterinary administration.

As a water-soluble precursor that converts in vivo to active benzodiazepine metabolites, it provides chemists and pharmacologists with a valuable model compound for studying sedative-hypnotic mechanisms, metabolic routes, and forensic toxicology in controlled settings. Researchers in the UK, USA, Germany, Australia, and across Asia rely on our secure logistics, careful packing, and stable supply to keep their workflow consistent and data driven.

What is Rilmazafone Rhythmy 450191 S

Rilmazafone (Japanese trade name Rhythmy, code 450191 S) is described in the literature as a water soluble benzodiazepine prodrug developed by Shionogi for the short term treatment of insomnia. Inside the body, it is metabolized by intestinal aminopeptidase enzymes to form active triazolobenzodiazepine metabolites, mainly rilmazolam, which bind to the GABA(A) benzodiazepine site and produce sedative and hypnotic effects.

According to summaries from DrugBank and Wikidoc, Rilmazafone itself shows little to no direct affinity for benzodiazepine receptors before metabolism, which is why it is classed as a prodrug rather than a conventional benzodiazepine. It has a reported molecular formula of C({21})H({20})Cl(_2)N(_6)O(_3) and a molar mass of around 475 g mol, making it suitable for detailed analytical and structural work in the lab.

At Davechemicals.com Rilmazafone we supply this compound strictly as a research chemical for analytical, forensic, and in vitro work, with no advice or encouragement regarding human use. Our entire catalogue, from alprazolam powder to synthetic cannabinoids like JWH 018, is sold under the same laboratory only condition.

Why researchers study Rilmazafone in the lab

Scientists working with Rilmazafone Rhythmy 450191 S are usually interested in three main areas.

• Characterising how non benzodiazepine looking prodrugs convert into classic triazolobenzodiazepines in the gut.
• Comparing the onset, duration, and metabolite profile to well known sedatives such as alprazolam, etizolam, or bromazolam, which are covered in reference sources like Drugs.com, DrugBank, and PsychonautWiki.
• Assessing its appearance in forensic casework, since Rilmazafone has recently appeared as a new psychoactive substance in Europe and has been involved in at least one documented fatal case in Sweden according to a 2023 PubMed indexed report.

Advisory documents from regulators, including a Medsafe classification review, highlight that Rilmazafone is approved as a prescription hypnotic in Japan but unscheduled in major markets such as the USA, much of Europe, and Australia, although status can change. That mix of clinical use in one country and legal ambiguity elsewhere is exactly why many forensic and policy focused labs are now paying attention to what is Rilmazafone and how it behaves in biological samples.

For researchers interested in broader benzodiazepine chemistry, related products such as bretazenil, diclazepam, flubromazolam, and bromazolam are available in our catalogue for cross comparison work.

What is Rilmazafone Rhythmy 450191 S for labs

From a pure laboratory perspective, Rilmazafone ticks several boxes that make it attractive to chemists in the UK, USA, Germany, Australia, and Asia.

• Water solubility facilitates use in aqueous test systems and simplifies formulation research compared with many classic benzodiazepines, which are highly lipophilic.
• Defined metabolic pathway to rilmazolam and related triazolobenzodiazepines enables repeatable pharmacokinetic modelling and metabolite profiling.
• Pharmacology that is centred on the GABA(_A) receptor complex provides a clear framework for receptor binding and functional assays using data from reference platforms such as DrugBank and Drugs.com.

On Davechemicals.com we present Rilmazafone with detailed batch documentation so that research teams can integrate it into wider projects involving designer benzodiazepines, novel sedatives, or combined datasets that also include compounds such as gidazepam or nitazene derivatives like isotonitazene and etonitazepipne.

For research purposes, not for human consumption. No dosing, no routes of administration, no advice regarding personal use.

Chemical profile of Rilmazafone Rhythmy 450191 S

According to public data collected on Wikipedia, Wikidoc, and regulatory briefs, Rilmazafone has the molecular formula C({21})H({20})Cl(_2)N(_6)O(_3) and a molar mass around 475 g mol. Chemically, it is an alozafone derivative that only forms a classic benzodiazepine ring after metabolic activation, which is unusual compared with common benzodiazepines that already contain the fused benzene diazepine core.

A New Zealand Medsafe review describes Rilmazafone as a benzodiazepine prodrug that is prescribed in Japan for short term insomnia, with a maximum recommended duration of about 4 weeks to limit dependence risk. The same document notes that in the USA, Europe, Canada, and Australia it is unscheduled at the time of writing, although importation can still be restricted under general psychoactive substance or medicine regulations.

For labs that need to compare what is Rilmazafone against other GABAergic agents, references from Cayman Chemical and harm reduction resources such as TripSitter and PsychonautWiki are often used to map effect profiles and receptor interactions, even though those platforms explicitly warn against uncontrolled personal use.

Table 1. What is Rilmazafone Rhythmy 450191 S

Key Laboratory Facts About Rilmazafone

Note: Legal status is fluid, researchers must check current local law before ordering or handling Rilmazafone.

How does Rilmazafone work in the body

From the available data, the sequence is straightforward.

1. Ingestion and metabolism
   • Rilmazafone itself shows little direct activity at benzodiazepine receptors.
   • Enzymes in the small intestine cleave the molecule, causing a ring closure that yields rilmazolam and related active metabolites.
2. Receptor interaction
   • These metabolites bind to the benzodiazepine binding site on the GABA(_A) receptor complex, positively modulating GABA and enhancing inhibitory signalling in the central nervous system.
   • The net effect, in a therapeutic setting, is sedation, hypnosis, and impaired motor coordination that resembles other short acting benzodiazepines.
3. Forensic interest
   • An ACMD style report and a 2023 forensic case series both highlight Rilmazafone as part of the new psychoactive benzodiazepine wave, after it was encountered in seized material and at least one fatality in Sweden.

For researchers working with other designer benzodiazepines, related molecules such as flunitrazolam, nitrazolam, and flualprazolam provide useful comparators when mapping receptor affinity and metabolic stability side by side.

Table 2. Rilmazafone Rhythmy 450191 S compared with classic benzodiazepines

Key Pharmacological Contrasts for Lab Work

Researchers in the UK, USA, Germany, Australia, and Asia often run these comparisons in parallel experimental designs to characterise risk and detectability.

Where to buy Rilmazafone for research in UK, USA, Germany, Australia, Asia 🌍

If you are asking where to buy Rilmazafone Rhythmy 450191 S for legitimate laboratory work, our Rilmazafone product page is designed for exactly that need. Our position is clear.

• Supply is for research purposes only, not for human consumption, not for clinical use, not for veterinary use.
• We serve registered labs in the United Kingdom, United States of America, Germany, Australia, and Asia, subject to successful screening and compliance checks.
• Orders can be combined with other investigative compounds such as 3 MeO PCP, 2 FDCK, ketamine analogues, or synthetic cannabinoids for broader projects.

For laboratories that want a deeper context on designer benzodiazepines and their place within wider drug markets, our blog coverage, such as benzo research chemicals and benzodiazepine friendly doctors near me, gives a candid overview of how these compounds appear from both clinical and grey market angles.

If you need tailored support or a bulk quote, Davechemicals.com contact is the quickest route to our team

Safety, legality, and research only disclaimer

Public agencies such as Medsafe and advisory councils on misuse of drugs note ongoing concern about non prescribed access to designer benzodiazepines including Rilmazafone, given association with dependence, cognitive impairment, and overdose when misused. Forensic reports on novel benzodiazepines show that mixing them with alcohol, opioids, or other central nervous system depressants increases the likelihood of respiratory depression and fatal outcome, which is why authorities watch this class closely.

Our commitment as Davechemicals.com is straightforward.

• All products, including Rilmazafone Rhythmy 450191 S, fentanyl powder, and U 47700, are sold exclusively as research chemicals.
• We do not provide usage advice, dosing guidance, or harm reduction counselling. External sites such as TripSitter and PsychonautWiki already stress the serious risks associated with non medical benzodiazepine use, including blackouts and severe withdrawal.
• Buyers are expected to know and respect the law in their own jurisdiction before ordering or handling any material from our store.

Table 3. Key Rilmazafone risks relevant to forensic and academic research

These points are not consumer advice, they provide context for why forensic and toxicology labs are keen to work with analytical grade Rilmazafone.

Related products for benzodiazepine and sedative research

Labs investigating what is Rilmazafone usually work with a wider set of GABAergic tools. On Davechemicals.com shop you will find:

• Short acting benzo analogues such as etizolam, flunitrazolam, norflurazepam, nitrazolam.
• Prodrug and atypical benzodiazepines such as gidazepam and adinazolam, useful for contrasting metabolic pathways with Rilmazafone.
• Sedative adjuncts and opioids like carfentanil, protonitazene, and metonitazene, which allow modelling of polydrug combinations already reported in forensic toxicology.

For broader stimulant or psychedelic comparison work, research teams often bundle Rilmazafone with compounds like 3 MMC, mephedrone, 1P LSD, or 5 MeO DMT to build multiparameter datasets that track sedation, stimulation, and perception altering action in parallel models.

FAQs, What is Rilmazafone Rhythmy 450191 S

1. What is Rilmazafone Rhythmy 450191 S in simple terms
Rilmazafone is a water soluble benzodiazepine prodrug that is inactive at benzodiazepine receptors until the body converts it to active triazolobenzodiazepines such as rilmazolam. It has been used as a short term prescription hypnotic in Japan, while remaining unscheduled but monitored in several other regions.

2. Is Rilmazafone legal in the UK, USA, Germany, Australia, and Asia
Medsafe and advisory documents state that Rilmazafone is unscheduled in the USA, Europe, Canada, and Australia, while authorised as a hypnotic in Japan, but local laws can still treat it as a medicine or psychoactive substance. Because legislation changes frequently and can differ within regions, researchers must verify current regulations locally before buying Rilmazafone or any other benzodiazepine prodrug.

3. Is Rilmazafone safe for personal use
Clinical sources describe benzodiazepines and related prodrugs as carrying significant risks including dependence, tolerance, cognitive impairment, and overdose, especially when mixed with alcohol or opioids. For that reason Rilmazafone is supplied on Davechemicals.com strictly as a research chemical, not for human consumption, with no dosing or usage guidance offered.

4. How is Rilmazafone different from regular benzodiazepines like alprazolam
Unlike alprazolam, Rilmazafone does not contain a benzodiazepine ring until an enzymatic reaction in the gut converts it to rilmazolam and related metabolites. Both ultimately act on the GABA(_A) benzodiazepine site, but the prodrug nature of Rilmazafone gives it a distinct metabolic and analytical profile of interest to pharmacologists and forensic chemists.

5. Where can research labs buy Rilmazafone online
Labs in the United Kingdom, United States of America, Germany, Australia, and Asia can order Rilmazafone Rhythmy 450191 S from Davechemicals.com Rilmazafone, subject to screening and legal compliance. Our store also lists related benzodiazepines and prodrugs such as etizolam, bretazenil, and gidazepam for comparative projects.

6. How pure is Davechemicals.com Rilmazafone
We supply Rilmazafone as a high purity research grade compound, with supporting documentation available on request via Davechemicals.com contact. Each batch is intended for analytical and experimental work, not for clinical or personal administration.

7. Can Rilmazafone be detected in standard drug tests
Forensic sources indicate that as a newer benzodiazepine prodrug, Rilmazafone and its metabolites may not appear on older immunoassay panels, yet they are detectable using targeted LC MS or GC MS techniques once parameters are set. This is one reason forensic labs obtain authentic Rilmazafone standards from suppliers such as Davechemicals.com to update their screening libraries.

8. Is Rilmazafone addictive
Benzodiazepine class agents, including those formed from Rilmazafone, are widely associated with dependence and withdrawal in both clinical and non medical contexts according to regulatory and clinical sources. That risk profile is why Rilmazafone is restricted to short term use in Japan and is treated cautiously by toxicologists when encountered as an NPS.

9. What research applications suit Rilmazafone best
Current literature points to pharmacokinetic modelling, receptor binding studies, and forensic toxicology as the most common applications for Rilmazafone Rhythmy 450191 S. Its prodrug design lets scientists watch in real time how enzyme mediated ring closure generates active benzodiazepines from a non benzodiazepine core.

10. Does Davechemicals.com offer bulk or repeat order options for Rilmazafone
Yes, research institutes and commercial labs that require a consistent supply of Rilmazafone can arrange repeat orders or bulk quantities by contacting our team via Davechemicals.com contact. We can also bundle Rilmazafone with other research chemicals such as MDPV, amphetamine powder, or lidocaine powder for wider project needs.

Key takeaways and call to action ✅

• Rilmazafone Rhythmy 450191 S is a water soluble benzodiazepine prodrug that only becomes active after enzymatic conversion to triazolobenzodiazepines such as rilmazolam.
• It is an approved short term hypnotic in Japan and an unscheduled but monitored compound elsewhere, which has prompted growing interest from forensic and pharmacology labs.
• Our Rilmazafone product page offers high purity research grade material for labs in the UK, USA, Germany, Australia, and Asia, strictly for research purposes only, not for human consumption.

If your lab is ready to explore what is Rilmazafone Rhythmy 450191 S in a controlled, professional setting, visit Davechemicals.com Rilmazafone or reach out through Davechemicals.com contact to discuss stock, pricing, or documentation for your next project.

1 2 3 4 5 6 7 8 9 10

Explore our blog for additional insights:

• Buy Rilmazafone Online
• Rilmazafone for Anxiety Treatment
• Rilmazafone Experience Report