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Buy Proscaline online – What is Proscaline (4 propoxy 3,5 dimethoxyphenethylamine)

Proscaline (systematic name 4-propoxy-3,5-dimethoxyphenethylamine) is a phenethylamine class compound with psychedelic properties. It is a structural analogue of mescaline, a naturally occurring psychedelic alkaloid originally isolated from Lophophora williamsii (peyote) cacti. (Wikipedia)

The academic literature and chemical databases describe Proscaline in terms of its chemical structure, receptor interactions, and limited documented use in research contexts. It is referenced in classic phenethylamine compilations such as Alexander Shulgin’s PiHKAL, but comprehensive human research remains very limited. (Wikipedia)

According to Frontiers in Pharmacology, scalines such as Proscaline show relevant interactions at 5 HT2A and 5 HT2C serotonin receptors in vitro, which are key receptors involved in psychedelic pharmacology in animal models. Public sources like Wikipedia and specialist resources, including PsychonautWiki, consistently describe Proscaline as a psychedelic phenethylamine of purely experimental status, not an approved medicine, not evaluated for safety, and not suitable for human use.

At Davechemicals.com Proscaline product page we position Proscaline powder strictly as a forensic and analytical reference material, supporting research teams who need a reliable standard for method development, cross reactivity studies, or comparative receptor work.

Chemical Profile of Proscaline

Structure and Classification

Proscaline is part of the phenethylamine family, a class of aromatic amines with diverse applications in organic chemistry and psychopharmacology. In chemical nomenclature, it is identified as 2-(3,5-dimethoxy-4-propoxyphenyl)ethan-1-amine and is closely related to other mescaline analogues. (Wikipedia)

Table 1. Chemical Profile Summary of Proscaline Notes: Lipophilicity data indicates higher relative membrane permeability than mescaline. (Wikipedia)

History and Discovery

The compound was first synthesised in the early 1970s and later examined by chemists such as Alexander Shulgin. Shulgin documented its formulation and relative potency compared with mescaline in PiHKAL, estimating greater potency on a weight basis. (Wikipedia)

Unlike many compounds, Proscaline did not gather broad research interest outside niche chemical circles. It subsequently appeared in limited academic literature analysing substituted phenethylamines and their structure-activity relationships. (GRECC)

Why researchers study Proscaline 4 propoxy 3,5 dimethoxyphenethylamine in the lab

Analytical and pharmacology labs in the United Kingdom, United States, Germany, Australia and Asia look at compounds like Proscaline 4 propoxy 3,5 dimethoxyphenethylamine for several reasons.

• To investigate structure activity relationships within the mescaline and scaline families, focusing on how 4 propoxy substitution alters 5 HT receptor binding and functional response.
• To expand toxicology libraries and LC MS databases so clinical and forensic labs can correctly flag unknown phenethylamines in casework.
• To compare Proscaline with other mescaline style analogues such as methallylescaline and allylescaline in receptor assays and metabolic profiling.

Sources like PsychonautWiki and Tripsitter characterise Proscaline as a long acting psychedelic with mescaline like features based mainly on anecdotal reports, which underlines how thin the formal evidence base still is. Drugs.com and DrugBank do not list Proscaline as an approved therapeutic agent, highlighting its research only status.

Our role at Davechemicals.com is to supply high consistency research chemicals such as Proscaline, 4 ACO DMT fumarate or dipropyltryptamine DPT, so scientists can work with known material rather than unknown street samples.

Caption: “High resolution analytical reference sample of Proscaline 4 propoxy 3,5 dimethoxyphenethylamine in amber glass vial for laboratory use only.”

How does Proscaline 4 propoxy 3,5 dimethoxyphenethylamine compare to mescaline and scalines

According to Wikipedia and receptor profiling work published in Frontiers in Pharmacology, Proscaline sits within a cluster of 4 alkoxy 3,5 dimethoxy phenethylamines sometimes called scalines. These compounds tend to show measurable activity at 5 HT2A and 5 HT2C receptors which are heavily studied in psychedelic research.

Below is a structured view of where Proscaline sits chemically.

Table 1. Proscaline and related mescaline family phenethylamines

Public data only, not safety guidance.

This cluster explains why many labs order Proscaline powder alongside methallylescaline, allylescaline and classic tryptamines such as 5 MeO DMT for comparative receptor and metabolism studies.

Legal status and safety warnings for Proscaline research

The legal status of Proscaline varies by jurisdiction:

• In the United Kingdom, it is classified as a Class A controlled substance under the Misuse of Drugs Act. (PsychonautWiki) • In Germany and Switzerland, it may be subject to new psychoactive substance regulations. (PsychonautWiki) • In the United States, it is not explicitly scheduled, but could be controlled under analogue legislation. (Wikipedia)

Legal classifications change over time and are dependent on national and regional law.

Where to buy Proscaline online for research safely

For labs that need a reliable source of Proscaline powder for research, we keep an optimised product workflow on our Buy Proscaline online page. Here is how we usually support serious customers.

Table 2. Why labs choose Davechemicals.com for Proscaline and related standards

If your project involves several phenethylamines, many customers combine Proscaline with buy mescaline powder, BOD 4 methyl 2,5 beta trimethoxyphenethylamine and tryptamine for sale to build a coherent SAR panel.

How researchers typically handle Proscaline 4 propoxy 3,5 dimethoxyphenethylamine in the lab

While every lab has its own SOPs, public safety guidance on phenethylamine handling and our own internal standards all point in the same direction.

Typical lab handling practices

• Use proper PPE, including gloves, lab coat, and suitable respiratory protection in case of dust, as used for other potent phenethylamines and designer drugs
• Work in a fume hood and keep Proscaline samples clearly labelled “research chemical, not for human or veterinary use”.
• Store in a cool, dry, secure environment away from unauthorised personnel, similar to handling MDPV or amphetamine powder.

Academic pharmacology reviews of psychedelics stress the need for careful control when working with compounds that modulate 5-HT2A receptors, even at small quantities. We extend that mindset across our catalogue, whether a lab orders Proscaline, 5 MeO MiPT for sale or dissociatives like N-ethyl ketamine and deoxymethoxetamine.

Best Proscaline 4 propoxy 3,5 dimethoxyphenethylamine alternatives for extended SAR projects

Some teams want Proscaline as part of a wider psychedelic research panel. In that case, researchers often group it with tryptamines and lysergamides to cover multiple scaffolds.

Table 3. Example research panel including Proscaline and complementary compounds

This kind of structure is common in receptor mapping and behavioural pharmacology work documented across psychedelic science, although Proscaline itself has only limited direct coverage in mainstream academic literature.

Risk, Toxicity and Harm Reduction

There is no reliable scientific literature describing Proscaline’s toxicity profile. Based on structure, it may share some elements with related compounds, but assumptions cannot be validated without pharmacological data. (PsychonautWiki)

Authors advising on research chemicals emphasise harm reduction and caution given the unknown risk profile. (PsychonautWiki)

Frequently asked questions about Proscaline 4 propoxy 3,5 dimethoxyphenethylamine ❓

1. What is Proscaline used for in a lab

Public data and receptor studies indicate that Proscaline 4 propoxy 3,5 dimethoxyphenethylamine is examined primarily in vitro as a psychedelic phenethylamine research tool, especially in 5 HT2A and 5 HT2C receptor work. Labs also employ Proscaline as an analytical reference standard to validate LC MS and GC MS methods when screening for mescaline style designer drugs.

2. Is Proscaline legal in the UK, USA, Germany, Australia or Asia

No single public source provides a clean global legal map for Proscaline, but general drug law references show that many countries control mescaline analogues by analogue or generic scheduling. As a result, Proscaline may be treated as a controlled analogue where used for human consumption, and researchers must check local law before ordering from Davechemicals.com or any other supplier.

3. Is Proscaline 4 propoxy 3,5 dimethoxyphenethylamine safe for human use

There is no robust clinical safety data for Proscaline in humans in the peer reviewed literature. Leading databases such as Drugs.com and DrugBank do not list Proscaline as an approved medicine, and at Davechemicals.com we clearly state that all such compounds are for research purposes only, not for human consumption.

4. How does Proscaline differ from mescaline

Chemically, mescaline carries three methoxy groups at positions 3, 4 and 5, while Proscaline has methoxy groups at 3 and 5, and a propoxy group at position 4, which shifts its receptor interaction profile. According to receptor work on 4 alkoxy 3,5 dimethoxy phenethylamines, extensions at the 4 position, such as propoxy, tend to increase binding affinity at 5-HT2A and 5-HT2C receptors, but this does not equate to proven safety or predictable human effects.

5. Where can researchers buy Proscaline online for research only

Research customers looking for high quality Proscaline powder for scientific use can order directly from our Buy Proscaline online page, where we outline packaging, shipping, and usage conditions. Many laboratories pair this purchase with other research only materials, such as buy 2 FDCK online, buy ibogaine online or buy mephedrone online for a broader internal library.