Buy Nitromethaqualone online (CAS Number: 340-52-3)
Buy Nitromethaqualone (CAS Number: 340-52-3) is a quinazolinone-class central nervous system depressant that acts as a sedative and hypnotic research compound. It is a structural derivative of methaqualone, modified with a nitro group on the phenyl ring, which alters its potency and pharmacological profile.
According to sources such as PsychonautWiki and a Cayman Chemical safety data sheet, Nitromethaqualone interacts with GABA_A receptor sites, enhancing inhibitory signalling in the brain, which explains its strong sedative and muscle-relaxant profile. In research contexts, it is treated as a high-risk psychoactive reference standard that requires strict handling controls and clear documentation.
Composition and Structure
Nitromethaqualone shares a structural analogue relationship with metaqualone, a sedative drug known for its hypnotic effects. This relationship stems from the similarities in their chemical structures, with nitromethaqualone exhibiting certain modifications that result in increased potency. Chemically, nitromethaqualone is composed of specific molecular components that contribute to its sedative properties, making it a compelling option for those seeking effective sedation.

| Synonyms | Nitromethaqualone |
| IUPAC | 3-(2-methoxy- |
| Formula | C16H13N3O4 |
| Molecular weight | 311.3 g·mol |
| CAS | 340-52-3 |
| Purity | ≥ 98% |
Potency and Dosage
Why researchers care about Nitromethaqualone (pharmacology, structure, effects)
Chemically, Nitromethaqualone is often described as 3,4-dihydro-2-methyl-3-(2-nitrophenyl)-4-oxoquinazoline, which reflects its quinazolinone core and nitro-substituted phenyl group. This structure places it in the same broad family as older sedative-hypnotics studied in the 1960s and 1970s, although Nitromethaqualone itself has far less formal clinical literature than methaqualone.
Reports aggregated on PsychonautWiki describe Nitromethaqualone as a strong CNS depressant with physical effects such as sedation, dizziness, muscle relaxation, motor control loss, and risk of respiratory depression at higher exposures. A Cayman Chemical data sheet lists oral and intraperitoneal LD50 values in mice (around the low gram per kilogram range), underlining that this is not a benign compound and belongs firmly in a hazardous research-only category.
How does Nitromethaqualone (CAS 340-52-3) work?
Laboratory and theoretical data frame Nitromethaqualone as a GABAergic modulator, similar in broad concept to benzodiazepines or barbiturates, by enhancing GABA-mediated inhibition in the central nervous system. This mechanism explains the typical sedative, hypnotic, and muscle relaxant characteristics that attract interest in pharmacological and forensic research.
However, although analogous compounds like methaqualone are extensively archived on platforms such as DrugBank and Drugs.com, public databases contain far fewer peer-reviewed pharmacokinetic studies on Nitromethaqualone itself, which is why credible suppliers and reference documents stress that its use must be restricted to controlled analytical work, not experimentation on humans.
Nitromethaqualone risks, safety profile, and toxicity
Available safety data for Nitromethaqualone classify it as toxic if misused and suitable only for trained personnel in controlled environments. The Cayman Chemical safety sheet notes mouse LD50 values around 930 to 982 mg/kg, with standard warnings relating to respiratory depression, CNS depression, and general toxicological uncertainty when extrapolated outside controlled laboratory settings.
Subjective-effect descriptions compiled on PsychonautWiki emphasise profound sedation, lethargy, motor impairment, and risk of respiratory depression at higher doses, which, in a non-clinical environment, would represent a serious safety threat. According to harm reduction sources such as TripSitter, similar sedative-hypnotic research chemicals have been linked to confusion, accidents, and risky polydrug use patterns, especially when combined with alcohol, opioids, or benzodiazepines.
Legal status and ethical sourcing of Nitromethaqualone
Formal scheduling for Nitromethaqualone varies by jurisdiction, but many countries now regulate methaqualone analogues and other novel sedative-hypnotics under analogue, psychoactive substances, or medicines legislation. In practice, this pushes Nitromethaqualone into a legal grey or controlled space, where only accredited laboratories, universities, or forensic institutions with appropriate permits can handle it legitimately.
European regulatory texts describe how new psychoactive substances and precursors are increasingly placed under control regimes that restrict use to tightly defined scientific, analytical, and forensic applications. For that reason, ethical sourcing from a trusted lab-focused supplier such as the Davechemicals.com official website is essential for any group that wants to remain compliant and maintain transparent documentation of procurement, batch data, and intended use.
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At Davechemicals.com, our role is simple: we supply high-purity research chemicals to verified laboratories that know exactly what they are doing, and we do it with clarity and honesty rather than marketing fluff. Nitromethaqualone (CAS Number: 340-52-3) sits in a niche corner of the sedative-hypnotic landscape, so we treat it with high scrutiny and strict internal quality standards.[2]
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How Nitromethaqualone compares with other sedative research compounds
Below is an at-a-glance comparison for researchers who also work with other depressant and psychoactive standards such as benzodiazepines, nitazenes, and synthetic cannabinoids.[1][2]
Table 1: Sedative-type research compounds compared
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| Compound | Primary class | Main researched effect | Typical research use | Example related product on Davechemicals.com |
|---|---|---|---|---|
| Nitromethaqualone (CAS 340-52-3) | Quinazolinone CNS depressant | Sedative, hypnotic, muscle relaxation | Reference standard for analytical and forensic work on sedative-hypnotics | Nitromethaqualone (CAS 340-52-3) via Davechemicals.com |
| Flualprazolam | Triazolo-benzodiazepine CNS depressant | Strong anxiolytic and sedative research profile | LC-MS / GC-MS benzodiazepine panel calibration | Buy flualprazolam online |
| Flunitrazepam | Benzodiazepine hypnotic | Powerful sedation, amnesia in clinical history | Forensic toxicology reference in benzodiazepine screening | Buy flunitrazepam for sale online |
| Bretazenil | Partial agonist benzodiazepine | Anxiolytic and sedative but with a partial agonist profile | Receptor binding and comparative potency studies | Buy bretazenil online |
Note: All listed materials are for laboratory research only, not for human or veterinary consumption.
Where to buy Nitromethaqualone (CAS 340-52-3) in the UK, USA, Germany, Australia, and Asia 🌍
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At Davechemicals.com shop, our catalogue and logistics are structured for international research clients, with shipping solutions that reflect local regulations, requirements for customs documentation, and the necessary data sheets for in-house compliance teams. For labs that routinely purchase high impact substances such as etonitazene, carfentanil or protonitazene, a consistent workflow with us makes adding Nitromethaqualone far simpler and safer.
Best practices for handling Nitromethaqualone in the lab
Serious research groups treat Nitromethaqualone like any other high-risk sedative research chemical, which means controlled access, detailed logs, and clear SOPs for storage and disposal. The Cayman Chemical safety sheet indicates that skin and eye irritation are not primary concerns, but general toxicology and CNS depression risks still demand gloves, protective eyewear, and appropriate fume control where dust or solution aerosols might arise.
We encourage all customers to integrate Nitromethaqualone into existing controlled substance management frameworks, alongside benzodiazepines, synthetic cannabinoids, and nitazenes, which many labs already monitor with internal audit trails and periodic stock checks. If your team is already working with materials such as ADB-FUBINACA, 5F-MDMB-2201 or JWH-018 spray, the same level of rigour should be applied to Nitromethaqualone.
Table 2: Nitromethaqualone key specifications and research context
Nitromethaqualone (CAS 340-52-3) research essentials
| Parameter | Description |
|---|---|
| Chemical class | Quinazolinone CNS depressant with structural similarity to methaqualone |
| CAS Number | 340-52-3, used for unambiguous catalogue and regulatory identification |
| Primary action | Modulation of GABA_A receptors, leading to sedative-hypnotic effects |
| Intended use | Analytical reference standard for forensic and pharmacological research only |
| Toxicology notes | LD50 in mice around 930–982 mg/kg, indicating significant toxicity at higher exposures |
| Regulatory environment | Often covered by analogue or psychoactive substance controls, subject to local law |
| Supply source | High-purity research-only material from Davechemicals.com to verified labs |
Footnote: Exact regulatory status must always be checked against local national legislation before ordering.
Table 3: Related research products often ordered alongside Nitromethaqualone
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| Research focus | Product | Use case |
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| Synthetic opioid comparison | Buy isotonitazene online | Investigating potency and toxicology of novel nitazenes compared with sedative-hypnotics |
| Cannabinoid receptor studies | Buy SGT-151 online | Synthetic cannabinoid reference for CB1 / CB2 receptor research and forensic screening |
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Frequently asked questions about Nitromethaqualone (CAS 340-52-3)
These FAQs reflect common queries found across major search engines and AI assistants when people search for “What is Nitromethaqualone”, “Nitromethaqualone effects”, “Nitromethaqualone legal status”, and related terms.
1. What is Nitromethaqualone used for in research?
Nitromethaqualone (CAS Number: 340-52-3) is used as a reference standard in pharmacological, toxicological, and forensic studies focused on sedative-hypnotic compounds. Labs use it to calibrate analytical instruments, investigate structure–activity relationships, and track emerging sedative-type substances in casework.
2. Is Nitromethaqualone legal in the UK, USA, Germany, Australia, or Asia?
There is no single global answer, since each country manages novel psychoactive substances and analogues under its own framework, often by grouping them under analogue, medicines, or psychoactive substance legislation. Many jurisdictions treat methaqualone analogues as controlled or controlled-by-analogy, so any lab interested in acquiring Nitromethaqualone must check current local schedules and, if required, obtain the appropriate licences or permits.
3. Is Nitromethaqualone safe for human consumption?
No. Available toxicology and harm reduction sources make it clear that Nitromethaqualone should not be used by humans, and it is sold strictly as a laboratory research chemical. Respiratory depression, deep sedation, and motor impairment are all realistic risks, especially if combined with other CNS depressants, which is why responsible suppliers such as Davechemicals.com flag it as research-only.[1][2]
4. How does Nitromethaqualone compare to benzodiazepines?
From a mechanistic viewpoint, both Nitromethaqualone and benzodiazepines interact with GABAergic systems, but they belong to different chemical classes and have distinct historical and regulatory backgrounds. Databases like Drugs.com and DrugBank present robust data on classic benzodiazepines, whereas Nitromethaqualone still sits in a sparsely documented niche, which increases the uncertainty around its risk profile for any non-research use.
5. Where can legitimate labs order Nitromethaqualone online?
Legitimate laboratories that have checked their local regulatory position can source Nitromethaqualone (CAS Number: 340-52-3) from specialist research suppliers such as Davechemicals.com. Our shop catalogue allows verified research accounts to order Nitromethaqualone alongside complementary reference standards such as EUK-134, Eutylone and MDPT for integrated projects.
Buy Nitromethaqualone online | Nitromethaqualone for sale online
- Nitromethaqualone (CAS Number: 340-52-3) is a quinazolinone sedative-hypnotic research compound, structurally related to methaqualone and active via GABAergic mechanisms.
- It carries real toxicological risks, is not for human use, and should only be handled by qualified personnel within accredited labs under clear SOPs and local legal compliance.
- For research entities in the UK, USA, Germany, Australia, and Asia searching for a reliable Nitromethaqualone supply, Davechemicals.com provides a straight-talking, documentation-focused route to this rare CNS depressant reference standard alongside a broader portfolio of analytical materials.
Call to action:
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