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EUK 134, also known as Ethylbisiminomethylguaiacol Manganese Chloride, stands as a premium synthetic antioxidant designed purely for research applications. With its unique ability to mimic superoxide dismutase (SOD) and catalase, this compound excels in neutralizing free radicals, making it invaluable for studies on oxidative stress, cellular protection, and anti-aging mechanisms. Featuring a molecular formula of C18H18ClMnN2O4 and CAS number 81065-76-1, our high-purity EUK 134 ensures reliable results in lab settings. At Davechemicals.com, we offer this essential research chemical with fast shipping to the United Kingdom, United States of America, Germany, Australia, and Asia. Remember, this product is strictly for research purposes, not for human consumption. Ready to elevate your investigations? Buy EUK 134 online from us today.
This powerful antioxidant has captured the attention of scientists worldwide for its potential in various studies. Whether you seek to understand cellular protection or explore anti-aging pathways, EUK 134 offers a robust tool. We ensure every batch meets stringent purity standards, typically above 98 percent, as verified through rigorous testing.
Imagine a molecule that tirelessly neutralizes harmful free radicals, regenerating itself to keep working long after application. That is the essence of EUK 134. In our labs, we have seen how this compound stands out in experiments, providing insights that push boundaries. If you are ready to incorporate it into your work, consider our range of related products, such as buy etonitazene online for complementary analgesic research or buy isotonitazene online for opioid-related investigations.
What Is EUK 134? Unpacking the Science Behind This Powerful Antioxidant
EUK 134, scientifically termed Ethylbisiminomethylguaiacol Manganese Chloride, represents a breakthrough in synthetic antioxidants. Developed as a salen-manganese complex, it replicates the functions of superoxide dismutase (SOD) and catalase, two vital enzymes in biological systems. According to data from PubChem, its molecular weight is 416.74 g/mol, with a structure featuring a central manganese atom coordinated to organic ligands.
This compound excels at scavenging reactive oxygen species (ROS), converting superoxide anions into harmless water and oxygen. Researchers often turn to EUK 134 for its self-regenerating properties, which allow sustained activity in experimental setups. In skincare contexts, though we emphasize research use only, studies highlight its role in reducing lipid peroxides on skin surfaces, as noted in work from the International Journal of Cosmetic Science.
We at Davechemicals.com source EUK 134 from trusted suppliers, ensuring it arrives as a crystalline solid ready for dissolution in appropriate solvents. Its CAS number, 81065-76-1, guarantees traceability in your protocols.
Chemical Properties of EUK 134
| Property | Details | Notes |
|---|---|---|
| Molecular Formula | C18H18ClMnN2O4 | Confirmed by PubChem |
| Molecular Weight | 416.74 g/mol | Standard value |
| CAS Number | 81065-76-1 | Universal identifier |
| Appearance | Crystalline solid | Stable form |
| Solubility | DMSO, ethanol | For lab use |
| Purity | ≥98% (HPLC) | As supplied by Cayman Chemical |
| Storage | -20°C, dry | To maintain activity |
Caption: Detailed Chemical Profile of EUK 134. Use this for protocol planning.
Why Choose EUK 134 for Your Research? Key Benefits Revealed
Why does EUK 134 stand out among antioxidants? Its dual mimetic action provides broad-spectrum protection against oxidative stress, a factor in many pathological models. For instance, in rat studies on ischemic brain injury, EUK 134 reduced infarct volume by over 80 percent when administered at 2.5 mg/kg, as detailed in research from the Journal of Pharmacology and Experimental Therapeutics.
Benefits include:
- Neuroprotection: Mitigates damage from excitotoxins like kainic acid.
- Renal Safeguard: Preserves blood flow in lipopolysaccharide-induced models.
- Muscle Recovery: Improves calcium handling in fatigued tissues.
In cosmetic research, it lowers erythema and enhances cell survival post-UV exposure. A study in the Journal of Investigative Dermatology30399-2/fulltext) showed it inhibits MAPK pathways activated by membrane damage.
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Key Takeaways:
- EUK 134 regenerates itself, offering prolonged efficacy.
- It targets multiple ROS, unlike single-action antioxidants.
- Proven in animal models for organ protection.
How Does EUK 134 Work? A Deep Dive into Its Mechanism
At the molecular level, EUK 134 acts by cycling between oxidation states, facilitated by its manganese core. It dismutates superoxide to hydrogen peroxide, then decomposes the peroxide into water and oxygen. This process, described in detail by Cayman Chemical, occurs with an initial reaction rate of 234 µM/min for hydrogen peroxide consumption.
In cellular assays, it prevents p53 accumulation in keratinocytes exposed to UVB, promoting survival. Researchers have observed reduced lipid peroxidation in skin models, compensating for seasonal antioxidant deficits. As per findings in MDPI, it maintains renal perfusion during oxidative challenges.
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To better grasp EUK 134, consider an illustration of its salen-manganese framework. Caption: “3D rendering of Ethylbisiminomethylguaiacol Manganese Chloride, showcasing the central manganese atom bound to nitrogen and oxygen ligands for optimal ROS scavenging.”
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- Purity guaranteed at ≥98%.
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Where to Find High-Quality EUK 134? Our Sourcing Standards
Sourcing EUK 134 demands precision. We partner with reputable manufacturers like those mirrored in Sigma-Aldrich, maintaining HPLC-verified quality. This ensures your research on oxidative stress yields reproducible data.
When to Use EUK 134 in Experiments: Timing and Dosage Insights
Timing matters in EUK 134 applications. In stroke models, post-event administration at 2.5-10 mg/kg proved effective, per Proceedings of the National Academy of Sciences. For in vitro, concentrations around 10-50 µM suffice for ROS quenching.
Why EUK 134 Outshines Other Antioxidants: A Comparison
EUK 134 offers advantages over natural enzymes due to its stability and regeneration. Unlike vitamin C, it avoids pro-oxidant risks at high doses.
Here is a centralized table comparing key antioxidants:
| Antioxidant | Mechanism | Regeneration | Research Applications | Purity Typically Available |
|---|---|---|---|---|
| EUK 134 | SOD/Catalase mimetic | Yes | Neuroprotection, renal studies | ≥98% |
| Vitamin C | Electron donor | No | Skin brightening, immune support | 99% |
| Resveratrol | Polyphenol scavenger | Partial | Anti-aging, cardiovascular | 95-99% |
| N-Acetyl Cysteine | Glutathione precursor | No | Detoxification, mucolytic | 98% |
| Coenzyme Q10 | Mitochondrial protector | Yes | Energy metabolism, heart health | 98% |
Caption: Comparison of EUK 134 with Common Antioxidants. Data sourced from various studies; consult primary literature for specifics.
Footnote: Dosages vary by model; always validate experimentally.
Which EUK 134 Variant Suits Your Needs? Purity and Forms
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Best EUK 134 for Oxidative Stress Research in the United Kingdom
For researchers in the United Kingdom focusing on oxidative stress, EUK 134 provides unmatched tools. Its ability to attenuate nitrosative stress, as in Chemico-Biological Interactions, makes it essential.
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Semantic Keywords: Antioxidant Mimetic for Cellular Protection
Antioxidant mimetic like EUK 134 bolsters cellular protection against environmental stressors. Studies in Nature Reviews Drug Discovery position it as promising for disease models.
List of Applications
- Ischemia-reperfusion injury.
- UV-induced skin damage.
- Neurodegenerative simulations.
- Muscle fatigue recovery.
- Pulmonary hypertension models.
Key Takeaways on Safety
EUK 134 shows low toxicity in models, with no major side effects at research doses. The Environmental Working Group rates it low hazard.
How to Store and Handle EUK 134 Safely
Store at -20°C in a dry, dark place. Use gloves during handling, as per standard lab protocols.
Large Table: Studies on EUK 134 Benefits
| Study Title | Year | Key Findings | Model Used | Dosage | Source |
|---|---|---|---|---|---|
| Synthetic SOD/Catalase Mimetics in Rat Stroke Model | 1998 | Reduced infarct by >80% | Rat MCA ligation | 2.5 mg/kg | J Pharmacol Exp Ther |
| EUK-134 Attenuates Kainate Neuropathology | 1999 | Prevented oxidative stress | Rat systemic kainic acid | 10 mg/kg | PNAS |
| EUK-134 Inhibits MAPK in Keratinocytes | 2004 | Lowered p53, increased survival | Human keratinocytes UVB | In vitro | J Invest Dermatol30399-2/fulltext) |
| Compensates Antioxidant Deficiency on Skin | 2004 | Reduced lipid peroxides | Human skin surface | Topical | Int J Cosmet Sci |
| Preservation of Renal Blood Flow | 2015 | Blocked LPS-induced fall | Piglet LPS model | In vivo | MDPI |
| Improves SR Ca2+ Release in Muscle | 2019 | Enhanced recovery post-fatigue | Mouse muscle | In vivo | Am J Physiol Regul Integr Comp Physiol |
| Electrotactic Exercise and EUK-134 | 2021 | Rejuvenation effects | Rat oxidative models | Combined | PMC |
Caption: Summary of Pivotal EUK 134 Research Studies. Centred for emphasis; mobile-responsive design.
Footnote: All studies animal or in vitro; extrapolate cautiously.
Another Table:
Frequently Asked Questions About EUK 134
- What is EUK 134 and how does it work? EUK 134 is a synthetic antioxidant that mimics SOD and catalase to neutralize free radicals, regenerating for ongoing protection in research.
- Can EUK 134 be used with other compounds like hyaluronic acid? Yes, it pairs well with non-acidic substances, but avoid strong acids or copper peptides to prevent deactivation.
- How often should researchers apply EUK 134 in models? Once daily suffices due to its self-regenerating nature, as seen in skincare analogs.
- What are the benefits of EUK 134 compared to vitamin C? It offers broader ROS coverage without pro-oxidant risks, excelling in stability for long-term studies.
- Are there any side effects or safety concerns with EUK 134? Low hazard rating; well-tolerated in models, but always handle as per lab safety guidelines.
- Where can I buy the best EUK 134 online in Australia? At Davechemicals.com, we provide high-purity options with shipping to Australia.
- Why is EUK 134 ideal for oxidative stress research in Germany? Its proven efficacy in European-standard labs makes it a go-to for German scientists.
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Key Citations
- PubChem: Ethylbisiminomethylguaiacol manganese chloride
- Cayman Chemical: EUK 134 Product Page
- Journal of Investigative Dermatology: EUK-134 Inhibits MAPK Pathways30399-2/fulltext)
- International Journal of Cosmetic Science: Antioxidant Deficiency Compensation
- MDPI: Preservation of Renal Blood Flow
- Proceedings of the National Academy of Sciences: Attenuates Kainate Neuropathology
- Nature Reviews Drug Discovery: Targeting Oxidative Stress




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