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What is 3F-PCP? Understanding the Basics of This Intriguing Compound 🔍
Picture a molecule that bridges classic pharmacology with modern innovation. 3F-PCP, or 3-Fluoro-PCP, emerges as a designer compound in the arylcyclohexylamine family, sharing roots with phencyclidine but distinguished by a strategic fluorine atom. This substitution alters its profile, making it a subject of keen interest for researchers exploring dissociative properties.
First spotted in Slovenia back in October 2020, as noted on Wikipedia, 3-Fluoro-PCP quickly entered the realm of research chemicals. Its chemical name, 1-[1-(3-fluorophenyl)cyclohexyl]piperidine, hints at its structured elegance, with a formula of C17H24FN and a molar mass around 261.38 g/mol. Scientists value it for potential insights into NMDA receptor interactions, similar to its parent compound.
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The molecular formula of 3F-PCP is C₁₇H₂₄FN•HCl, with a molecular weight of 297.8 g/mol. This compound exists primarily in crystalline form, which is ideal for precise dosing in research applications. The fluorine substitution at the 3-position of the phenyl ring modifies the compound’s binding affinity and overall pharmacological profile compared to traditional PCP.
Chemical Characteristics of 3F-PCP
| Property | Details |
|---|---|
| Chemical Name | 1-[1-(3-fluorophenyl)cyclohexyl]-piperidine, monohydrochloride |
| CAS Number | 1049718-37-7 |
| Molecular Formula | C₁₇H₂₄FN•HCl |
| Molecular Weight | 297.8 g/mol |
| Physical Form | Crystalline solid |
| Purity | ≥98% (research grade) |
| Solubility | DMF: 15 mg/ml, DMSO: 10 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml |
“The fluorine substitution in 3F-PCP significantly alters its pharmacological profile compared to traditional PCP, making it an interesting compound for researchers studying structure-activity relationships in arylcyclohexylamines.”
Pharmacological Profile and Effects
Research indicates that 3F-PCP produces dissociative effects similar to those of phencyclidine and other arylcyclohexylamines. As a non-competitive NMDA receptor antagonist, it induces a state of detachment from one’s body and surroundings, which has made it a subject of interest in neuroscience and pharmacology research.
Studies in animal models have shown that 3F-PCP induces discriminative stimulus effects comparable to those induced by PCP, suggesting similar mechanisms of action. However, the fluorine substitution may result in differences in potency, duration, and specific subjective effects that researchers find valuable for comparative studies.
Research Applications of 3F-PCP
Scientists utilize 3F-PCP in various research contexts, including:
- Neuropharmacology studies examining NMDA receptor function
- Structure-activity relationship investigations within the arylcyclohexylamine class
- Comparative pharmacology research contrasting different dissociative compounds
- Forensic science applications for detection and analysis methods development
The compound’s unique properties make it particularly useful for researchers seeking to understand how subtle chemical modifications affect the overall pharmacological profile of dissociative substances.
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How Does 3-Fluoro-PCP Work? A Deep Dive into Its Mechanisms 🧠
Curious about how 3-Fluoro-PCP works? This compound acts primarily as an NMDA receptor antagonist, blocking glutamate pathways much like PCP, but the fluorine may modulate potency. According to sources on PsychonautWiki, analogs like this induce dissociative states in controlled settings.
In research, 3F-PCP offers a window into neuropharmacology. It may influence dopamine and serotonin systems, leading to varied responses. While human data remains limited, animal studies from PubChem suggest altered binding affinities.
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Key Takeaways:
- 3F-PCP targets NMDA receptors.
- Fluorine addition potentially reduces certain risks compared to PCP.
- Ideal for studying dissociative mechanisms.
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Why Choose 3F-PCP Over Other Analogs? Comparative Analysis 🤔
Wondering why 3F-PCP stands out? Its fluoro modification may offer milder profiles than PCP, reducing some unpredictable elements, as discussed on Tripsitter.
Here’s a centralized table for clarity:
| Property | 3F-PCP | PCP | 3-MeO-PCP |
|---|---|---|---|
| Chemical Formula | C17H24FN | C17H25N | C18H27NO |
| Molar Mass | 261.38 g/mol | 243.39 g/mol | 273.42 g/mol |
| Primary Effect | Dissociative | Dissociative | Dissociative with stimulation |
| Discovery Year | 2020 | 1950s | 1970s |
| Research Focus | NMDA antagonism | Anesthetic origins | Manic potential |
| Purity at Davechemicals.com | ≥98% | N/A | ≥98% |
Table 1: Comparison of 3F-PCP with Related Analogs. Note: Data sourced from credible databases; consult for updates.
When Was 3F-PCP Discovered? Tracing Its Origins 📜
Asking when was 3F-PCP discovered? It surfaced in 2020, per European reports. This timeline underscores its novelty, fueling ongoing studies.
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Which Countries Allow 3-Fluoro-PCP for Research? Global Legality Overview 🌍
Navigating which countries allow 3-Fluoro-PCP? In Germany, it’s under NpSG for scientific use. Australia treats it as controlled, while Asia varies by nation. Always verify local laws.
| Country/Region | Legal Status | Notes |
|---|---|---|
| United Kingdom | Class B | Research permitted with licenses |
| United States | Analog Act applies | For lab use only |
| Germany | NpSG restricted | Industrial/scientific exemptions |
| Australia | Schedule 9 | Prohibited except research |
| Asia (e.g., Japan) | Varies | Often banned; check per country |
| Canada | Schedule I | Strict controls |
Table 2: 3F-PCP Legality Across Target Regions. Sources include government databases; laws evolve.
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Potential Research Applications of 3F-PCP: What Studies Suggest 📊
3F-PCP holds promise in modeling dissociative disorders. According to a study in The Journal of Pharmacology and Experimental Therapeutics21490-2), PCP derivatives aid structure-activity research.
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List of Applications:
- Neurotransmitter studies
- Forensic toxicology
- Behavioral assays
Risks Associated with 3-Fluoro-PCP: What Researchers Should Know ⚠️
While for research, 3-Fluoro-PCP risks mirror PCP: potential for psychosis, seizures, per Drugs.com. Handle with care.
A risks table:
| Risk Category | Description | Mitigation |
|---|---|---|
| Psychological | Anxiety, paranoia | Controlled environments |
| Physical | Increased heart rate | Lab monitoring |
| Addiction | Low potential | Ethical use |
| Overdose | Seizures possible | Precise dosing |
| Long-Term | Cognitive impacts | Limited exposure |
Table 3: Potential 3F-PCP Risks and Mitigations. Based on analog data from DrugBank.
How to Store 3F-PCP Properly: Tips for Longevity 🗄️
How to store 3F-PCP? Keep in cool, dry conditions, away from light. Our packaging supports this.
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Frequently Asked Questions About 3F-PCP ❓
- What is 3F-PCP used for in research? It’s employed in pharmacological studies on NMDA receptors, as per Tripsitter.
- Is 3-Fluoro-PCP legal in Australia? It’s controlled under Schedule 9, but research use is possible with permits.
- What are the effects of 3F-PCP? Dissociative and stimulant-like, though data is limited.
- How much 3F-PCP should be used in experiments? Dosages are unestablished; start minimal based on analogs.
- What risks come with handling 3-Fluoro-PCP? Potential for anxiety or physical strain; use PPE.
- Where can I buy 3F-PCP in Asia? Davechemicals.com ships globally with compliance.
- How does 3F-PCP compare to PCP? Milder due to fluorine, per structure-activity studies.
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