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Introduction to Clonazolam: A Potent Force in Research Chemicals
At Davechemicals.com, we supply premium research chemicals that fuel scientific discovery. One compound that stands out in our catalogue is Clonazolam, a substance that has captured the attention of researchers worldwide. This triazolobenzodiazepine, often referred to as Clonitrazolam, offers intriguing possibilities for studying neurotransmitter systems. Yet, its potency demands respect and careful handling.
Imagine a molecule so refined that it amplifies inhibitory signals in the brain with precision. That’s Clonazolam in action, binding to GABA receptors to produce effects that mimic, and sometimes surpass, traditional benzodiazepines.
The drug clonazepam, also advertised as Klonopin, is used to prevent and treat seizures, panic attacks, anxiety disorders, and the movement disorder akathisia. It belongs to the benzodiazepine (ben-zoe-dye-AZE-eh-peen) class of tranquillizers. Typically, it is ingested. The effects start to take effect within an hour and remain for six to twelve hours. Clonazepam was patented in 1960 and went on sale in 1975 in the United States from Roche. It is available as a generic medication.
What Is Clonazolam?
Clonazolam is a designer benzodiazepine analog, structurally derived from established compounds like clonazepam and alprazolam. According to Wikipedia, it features a fused triazole ring, classifying it as a triazolobenzodiazepine. Synthesised back in 1971, it was noted for its exceptional activity in early tests.
Chemically, Clonazolam has the formula C17H12ClN5O2, with a nitro group at the 7-position and a chlorine at the 2-prime spot, as detailed on PubChem. This structure enhances its affinity for GABA-A receptors, leading to potent neuroinhibitory effects. Researchers value it for modelling anxiety-related pathways, though its lack of clinical approval underscores its role strictly in labs.
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History of Clonazolam.
The story of Clonazolam begins in the 1970s, when scientists first characterised it as part of a benzodiazepine series. As per a critical review by the World Health Organization, it stood out for its pharmacological potency but never progressed to pharmaceutical markets.
By 2014, Clonazolam reappeared in illicit channels, prompting regulatory scrutiny. Sources like Taylor & Francis note its resurgence as a research chemical, driven by interest in novel psychoactive substances. Today, it remains unscheduled in some regions but controlled elsewhere, reflecting ongoing debates.
Our experience at Davechemicals.com shows researchers turning to Clonazolam for its unique profile. We recommend cross-referencing with PsychonautWiki for user-reported insights, though always prioritise peer-reviewed data.
Chemical Properties of Clonazolam:
Understanding the chemical properties of Clonazolam reveals why it demands caution. It acts by allosterically modulating GABA currents, as explained in the WHO report. Its half-life is around 3.6 hours, with metabolites like 7-aminoclonazolam excreted in urine.
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Table 1: Chemical Properties Comparison of Clonazolam and Related Compounds
| Property | Clonazolam | Clonazepam | Alprazolam |
|---|---|---|---|
| Molecular Formula | C17H12ClN5O2 | C15H10ClN3O3 | C17H13ClN4 |
| Molecular Weight | 353.76 g/mol | 315.71 g/mol | 308.76 g/mol |
| Structure Type | Triazolobenzodiazepine | Benzodiazepine | Triazolobenzodiazepine |
| Nitro Group Position | 7 | 7 | None |
| Chlorine Position | 2′ | 2′ | 8 |
| Solubility | Organic solvents | Water (slight) | Organic solvents |
| Half-Life | ~3.6 hours | 18-50 hours | 11-15 hours |
| Primary Metabolite | 7-Aminoclonazolam | 7-Aminoclonazepam | Alpha-Hydroxyalprazolam |
Caption: This table compares key chemical properties of Clonazolam with clonazepam and alprazolam, highlighting structural differences. Data sourced from PubChem and WHO reports. Note: All for research only.
Effects of Clonazolam.
The effects of Clonazolam include anxiolysis, muscle relaxation, and sedation, as outlined on Tripsitter. It enhances GABA activity, leading to neuroinhibition. In studies, doses as low as 0.2 mg show activity, but over 0.5 mg risks severe outcomes.
Side effects noted in literature, such as PMC article on designer benzodiazepines, include drowsiness, amnesia, and respiratory issues. Withdrawal can be harsh, with symptoms like anxiety and seizures.
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Why Choose Clonazolam for Research? Benefits and Insights
Researchers opt for Clonazolam due to its high affinity for receptors, offering models for dependence studies. A Federal Register notice highlights its pharmacological similarity to approved drugs, making it valuable for analogies.
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Table 2: Dosage Guidelines for Research Purposes
| Dose Level | Amount (mg) | Observed Effects in Studies | Risk Level |
|---|---|---|---|
| Threshold | 0.1-0.2 | Mild anxiolysis | Low |
| Common | 0.2-0.4 | Sedation, relaxation | Moderate |
| Strong | 0.4-0.5 | Amnesia, heavy sedation | High |
| Heavy | >0.5 | Overdose risk, blackout | Very High |
| Duration | 8-24 hours | Varies by metabolism | N/A |
| Onset | 20-60 minutes | Oral administration | N/A |
Caption: Research-oriented dosage table for Clonazolam, based on PsychonautWiki and Tripsitter. Not for human use; consult safety data.
Legal Status of Clonazolam: Where Can You Buy It? 🌍
The legal status of Clonazolam varies. In the United Kingdom, it’s Class C under the Misuse of Drugs Act. The United States of America lists it as Schedule I. Germany restricts it via NpSG. In Australia, it’s Schedule 9. Asia regions differ, with some unscheduled.
A Wellness Retreat article warns of its dangers, aligning with DEA placements. We ship compliantly; check local laws.
Toxicity and Harm Reduction: Essential Knowledge
Clonazolam‘s toxicity stems from its potency, with risks of overdose at low doses. Tripsitter advises against mixing with depressants.
In research, handle with gloves; avoid inhalation. We provide MSDS with every order.
Clonazolam enhances GABA effects, but its narrow therapeutic window demands caution,” from the WHO review.
Comparisons: Clonazolam vs Other Benzodiazepines
Clonazolam outshines many in potency. Versus etizolam, it’s stronger, per user forums on The Drug Classroom.
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Table 3: Legal Status of Clonazolam Worldwide
| Country/Region | Status | Details | Source |
|---|---|---|---|
| United Kingdom | Class C | Misuse of Drugs Act 1971 | UK Government |
| United States | Schedule I | DEA temporary placement | Federal Register |
| Germany | NpSG restricted | Industrial/scientific only | German Law |
| Australia | Schedule 9 | Prohibited substance | TGA |
| Asia (e.g., Canada) | Unscheduled in some | Varies by country | Health Canada |
| Brazil | Class B1 | Psychoactive controlled | ANVISA |
| Sweden | Hazardous suggested | Since 2015 | Public Health Agency |
Caption: Global legal status table for Clonazolam, compiled from Wikipedia and official sources. Always verify locally.
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What Is the Half-Life of Clonazolam?
Around 3.6 hours, with metabolites lingering longer, per Tripsitter.
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Yes, often reported as more potent, based on Reddit discussions.
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